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A senolytic combination only improved muscles with resistance training, not without it. IN this paper, the researchers cite their prior research showing that the SASP, in conjunction with its inflammatory effects, harms the ability of muscle progenitor cells to proliferate, thus depleting the ability of muscle to regenerate…

You have two choices when pondering how—and whether—you will live a long, healthy life. You can either apply the latest findings of longevity research to boost your odds. Or you can eat what you want, forgo health and wellness habits and figure it’s mostly genetics anyway. Most of…

A recent study by UK-based CBD company Eden's Gate sought to uncover the secrets to living a long life by studying some of the world's oldest people (via Eat This, Not That!). To get at the core of what gives individuals health and longevity, researchers examined the lifestyles of six people who lived to be older than 100. Their…

Key clinical point: Curcumin consumption for 8 weeks as a part of an integrated approach could help modulate metabolic factors, inflammation, and adiposity in women with rheumatoid arthritis (RA). After 8 weeks, insulin resistance, erythrocyte sediment…

Preliminary data from an artificial intelligence model could potentially predict side effects resulting from new combination therapies, according to results presented at the AACR Annual Meeting 2022, held April 8-13. Many cancer types are increasingly being treated with combination therapies, through which clinicians …

By combining CRISPR technology with a protein designed by AI, researchers from the University of Washington School of Medicine in Seattle have been able to awaken individual dormant genes by disabling the chemical “off switches” that silence them through gene therapy. Longevity. Technology: This gene therapy approach, which is described in Cell Reports, will allow…

Skin cells have been exposed to molecules that reverse their development but still retain their function, creating a kind of stem cell that keeps its original function in the body Researchers have developed a method that can turn back the biological clock on skin cells by 30 years, creating stem cells from mature ones, which could be used to treat skin conditions in the future.

Ginger and many other plants are widely known for their anti-inflammatory effects. Cellular senescence, in turn, plays a major role in the age-related chronic inflammation known as inflammaging [2]. This prompted an investigation into four plant extracts to see if any of them actually influence cellular senescence.

New senolytics data was released from Dr. James L. Kirkland's Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that α-Klotho protein decreases with age in mice and humans [2,3]. It has also been demonstrated that mice that lack α-Klotho have shorter lifespans, cognitive impairment, sarcopenia, vascular dysfunction, osteopenia, cardiac hypertrophy and fibrosis, and physical dysfunction [2-9].

Scientists at Newcastle University have shown that physical activity causes the cancer-fighting protein, interleukin-6 (IL-6), to be released into the bloodstream which helps repair the DNA of damaged cells. The findings, published in the International Journal of Cancer, sheds new light on the importance of moderate…

Sleep. Everyone knows it’s vital for our very survival. But why? What is happening in our bodies while we sleep? Understanding this fundamental question is the focus of research groups like the Appelbaum Lab at Bar-Ilan University in Israel. In 2019, Appelbaum, along with Dr David Zada and colleagues, published the results of a study in zebrafish, which proposed that the restorative function of sleep is …

Stem cells can develop into many different types of cells in the body. For instance, when a person is injured, stem cells come to the site of the injury and aid in healing damaged tissues. New nanotechnology developed by a team of researchers from Texas A&M University could leverage the body's regenerative potential by directing stem cells to form bone tissue…

Many people dread experiencing the cognitive and mood declines that often accompany reaching an advanced age, including memory disorders such as Alzheimer’s disease and mood conditions like depression. At Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital researchers have been investigating new ways to…

Aging is accompanied by an increase in chronic, low-grade inflammation, known as inflammaging, which has been linked to multiple age-related diseases. Inflammaging promotes cancer, diabetes, cardiovascular diseases, and various types of dementia, such as the deadly Alzheimer’s disease. Age-related cognitive decline is of particular concern to geroscientists since…

Imagine being able to record yourself reading and then having your clinician use those recordings to screen for various diseases, even from thousands of miles away. This technology may sound like science fiction, but Mayo Clinic researchers are using artificial intelligence (AI) to discover and test what the voice can reveal about a patient's heart health. In a recent study, the research team used an AI trained…

Fauna Bio, a biotechnology company pioneering the fields of comparative, computational and translational genomics, has announced a partnership with the University of Wisconsin OshKosh to accelerate the translation of human therapeutics and disease strategies discovered through research into extreme mammal adaptation…

People have traditionally thought of aging as an inevitable part of life. But since the seminal work of Cynthia Kenyon in the ’90s, researchers have also become aware that aging is under genetic control. Scientists continue to be interested in finding out whether the negative effects of aging can be reduced or reversed entirely. Currently, 16% of the United States population is 65 years or older. By 2050 this is expected to reach 22%.

At 79, he’s already outlived the CDC’s official life expectancy by two years and he has no intention of dying — or even slowing down — anytime soon. An active man, Scott jets between his homes in upstate New York and Florida, flies to exotic locations such as Panama City for business and still finds time for the odd cruise. His secret? A DIY regime of self-experimentation and untested therapies he believes will keep him…

Staying well-hydrated may be associated with a reduced risk for developing heart failure, according to research first presented external link at the European Society of Cardiology Congress in 2021. The findings, which recently published in the European Heart Journal external link , suggest that taking in sufficient amounts of fluids throughout life not only supports essential body functions, but .…

The plant-based version of omega-3 fatty acid, alpha-linolenic acid (ALA), can benefit heart health and reduce the risk of heart disease, according to new research published in medical journal Advances in Nutrition. Previous research has linked omega-3s with a lower risk of heart disease, but this conclusion was based on omega-3s from fish and other seafood. In a comprehensive literature review…

Dentures and implants could soon be a thing of the past following groundbreaking research by Polish scientists. The team from Poznań, Warsaw and Toruń are carrying out research into growing ‘third teeth’ based on stem cells found in human gums. Known as tissue engineering, the in vitro process uses substitutes for tissues or even entire organs. Project leader Agnieszka Gadomska-Gajadhur from…

Rejuvenate Biomed, a biomedical company developing novel combination drugs for age-related diseases, has announced it has commenced its first Phase 1 clinical trial assessing the company’s lead candidate RJx-01 for the treatment of sarcopenia. This trial marks Rejuvenate’s maturation from preclinical- to clinical-stage company and is accompanied…

A new approach from Penn Medicine researchers could cut the time it takes to alter patients’ immune cells for infusion back into the body to find and attack cancer. The cell manufacturing process for this type of immunotherapy that was pioneered at Penn — CAR T cell therapy — typically takes nine to 14 days. In a pre-clinical study published in Nature Biomedical Engineering, a team in the…

Having an unhealthy gut isn't just uncomfortable and painful, it can seriously impact your overall health in a negative way. Bad gut bacteria can cause depression, anxiety and can increase the risk of diabetes and obesity in addition to other health issues. Eat This, Not That! Health spoke with Miguel Freitas, Ph.D., VP of Health and Scientific Affairs at Danone North America who explained what causes an unhealthy…